Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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How to cite this article: List of the 4 accessions of Andrographis paniculata collected from Peninsular Malaysia. In fact, a positive correlation between metabolite enhancement flavonoid and proline and relative water content RWC was reported in rice [ 13 ], reiterating the notion that metabolic adaptations are part of a complex mechanism to overcome threads from stresses.

Plant-derived compounds act as a prevention within the development of many anti-cancer agents. But many cancer patients seek alternative and complementary methods of treatment because of the serious side effects of chemotherapy and radiation therapy.

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Among cancer especially prostrate cancer has been responsible for drastic mortality rate in males. Medicinal plants maintain the health and vitality of individuals and cure various diseases, including cancer without causing toxicity. A pilot double blind study. However, to prove their efficacy for paniculxta utilization more scientific data are needed.

Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

The correlative aspects of the three anticancer phytochemicals production as well as the accumulation of proline in the tolerant and sensitive A.

The relative amounts of phytochemicals in salt-tolerant a and salt-sensitive b accessions of A. The antioxidant phytochemicals protect the cells from oxidative damage. The filtrate was evaporated to dryness using a rotary evaporator yield was It is assumed that the accumulation of these phytochemicals in A. Hepatoprotective and antioxidant property of Andrographis paniculata Nees in BHC induced liver damage in mice. The colorimetric assay estimated cell number indirectly by staining total cellular protein with the dye SRB.


As an aerial organ, leaves are directly exposed to various biotic and abiotic stresses, which demand metabolic adaptations for survival.

The following drugs and chemicals were used: Salinity causes the adverse effects in all physiological processes of plants. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. Cytotoxic effect of Plantago spp. View at Google Scholar D.

Percentage inhibition was calculated by comparing the OD of control well with that of test sample: The sulphorhodamine B SRB assay was naticancer to assess growth inhibition of human tumor. The results obtained in the study indicate that A.

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Natural drugs have less toxicity than the commercially available drugs. These neutral organic compounds can also improve the inhibitory effects of high ion concentrations on enzymatic activity without interfering with protein structure and function [ 35 ].

It may lead to the accumulation or reduction of certain metabolites [ 1 — 3 ]. View at Google Scholar P. The combination of both the plants 1: Maintained cultures were passage weekly and the culture medium was changed twice a week. Salinity is a major abiotic stress that causes important alterations in the plant growth and development. Interestingly, the correlation between proline as well as NAG with the other measured morphological characteristics was significant and positive in the salt-stressed plants.


The extracts were then stored below ambient temperature for further studies.

Flavonoids isolated from Plantago species were able to strongly inhibit the proliferation of human cancer cell lines Galvez et al. In this regard, our results indicated that proline as well as the AG and NAG contents is positively correlated with the substrate concentration of salt, in which the tolerant accessions were higher in proline, AG, and NAG contents compared panivulata the sensitive ones.

Anticancer activity of hydroalcoholic extract of A. Journal of Pharmacology and Toxicology, 8: As a matter of fact, a andrograpjis of this enhancement could be due to an obvious reduction of the plant biomass.

On the basis of measurement of OD, the anticancer study suggest that S. After 30 days of culturing almost in 70 days oldthe plants were placed in different salinity levels. In the body normal cells complete their life cycle by following an orderly path of growth, division actovity death. The solvent extract was concentrated under reduced pressure using a rotary evaporator.

To receive news and publication updates for Activkty Research International, enter your email address in the box below. Introduction Salinity is a major abiotic stress that causes important alterations in the plant growth and development.