Anemia is a condition in which the body does not have enough healthy red Weakened stomach lining (atrophic gastritis); An autoimmune. Pernicious anemia probably is an autoimmune disorder with a genetic predisposition. The disease is more common than is expected in families. Pernicious anemia is thought to be an autoimmune disorder, and certain people may have a genetic predisposition to this disorder. There is a rare congenital.

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A low red blood cell count also can cause shortness of breath, dizziness, headache, coldness in your hands and feet, pale or yellowish skin, and chest pain. Severe vitamin B12 deficiency can cause neurological problems, such as confusion, dementia, depression, and memory loss.

Hemolytic disease of the newborn. The Editors of Encyclopaedia Britannica. Red blood cells provide oxygen to body tissues. A vitamin B12 nose aanemia and spray also are available.

Although the healthy body stores three to five years’ worth of B 12 in the liver, the usually undetected autoimmune activity in one’s gut over a prolonged period of time leads to B 12 depletion and the resulting anemia.

Weakened stomach lining atrophic gastritis An autoimmune condition in which the body’s immune system attacks the actual intrinsic factor protein or the cells in the lining of your stomach that make it.

Bone marrow is the spongy substance found in the center of the long bones of the body. This leads to vitamin B12 deficiency. Diseases that interfere with vitamin B12 absorption. Pernicious anemia due to autoimmune problems occurs in about one per people. Internet URLs are the best.


Megaloblastic anemia – view of red blood cells. Thank You for Your Contribution! Too many of the wrong kind of bacteria in the small intestine. Related Health Topics Anemia. Diet Lacking Vitamin B12 Some people get pernicious anemia because they don’t have enough vitamin B12 in their diets. Today, though, the disease is relatively easy to treat with B injections or supplements. D ICD – Your doctor also may check for signs of nerve damage. The initial symptoms may include diarrhea, vomiting, a profound loss of appetite anorexiaand weight loss.

InGerman physician Michael Anton Biermer — noticed the particular characteristic of the anemia in one of his patients; he later coined the term “progressive pernicious anemia”.

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More About Pernicious anemia 9 references found in Britannica articles Assorted References medicine In ;erniciosa of medicine: Detecting early flu symptoms can help…. The Merck Manual-Home Edition. Pernicious anemia is in most cases associated with an inflammation of the stomach called autoimmune gastritis. Your body sometimes requires more folate than normal. Human evolution, the process by which human beings developed on Earth from now-extinct primates.

Vitamin B12 deficiency anemia – Wikipedia

Learn More in these related Britannica articles: At the bottom of the article, feel free to list any sources that support your changes, so that we can fully understand their context. They can check for the start of cancer at autinmune visits and through biopsies. The most dangerous complication pernicios gastric cancer. This reaction is catalyzed by the enzyme methionine synthase with B 12 as an essential cofactor. Also, tell your family members, especially your children and brothers and sisters, that you have pernicious anemia.


Early diagnosis, treatment, and close monitoring are important for preventing any future problems. Other vitamin B deficiencies, such as those caused by poor diet, are often confused with pernicious anemia. Mosby’s manual of diagnostic and laboratory tests. This type of surgery autoinmund the number of parietal cells available to make intrinsic factor.

Pernicious anemia

The symptoms of long-term damage include:. In adults, symptoms of pernicious anemia pernicioda usually not seen until after age The body needs iron to produce hemoglobin.

After your B levels are normal, your doctor may recommend you take regular doses of B supplements instead of the injection. You get this vitamin from eating foods such as meat, poultry, shellfish, eggs, and dairy products. Another example autoinmun Crohn’s disease, an inflammatory bowel disease. Pernicious anemia also has other causes, besides a lack of intrinsic wutoinmune.

Affected infants may experience repeated episodes of extreme anemia and jaundice. Back to Vitamin B12 or folate deficiency anaemia.