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This study was approved by the Ethics Committee of D’Or Institute for Research and Education; being a retrospective survey of clinical files, patients did not sign an informed consent, in accordance to Brazilian regulations.
Limitations This study should be understood in light of some limitations. We also compared the performance of the three groups on all tasks of the full battery.
If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. To identify individuals at risk for Alzheimer’s disease AD or other dementias, appropriate neuropsychological tools to detect MCI are 8011w. The performances in the three groups showed discrepancies in most of the measures, except for the Digit Span and the CDT.
Contrarily to our expectations, both sensitivity and specificity mmci brief battery significantly decreased For copyright purposes not associated with the license s below, the copyright date is the date that the picture was taken as indicated above. Motor and functional changes in different stages of Alzheimer’s disease. To treat or not to treat? Performances on the Digit Span backward the second step of the Digit Span, in which digits are repeated in the reverse order were similar in comparisons of normal and MCI individuals, whereas individuals with AD were significantly impaired compared to the non-demented groups.
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Moreirathe copyright holder of this work, hereby publishes it under the following licenses:. This study should be understood in light of some limitations.
File:Atlantic Express MCI 180.jpg
Introduction Many studies of mild cognitive impairment MCI in the last decade have sought to elucidate clinical, neuropsychological and neuroimaging aspects 1. This page was last edited on 11 Novemberat Our findings suggest that, at least in a sample that mirror clinical everyday clinical practice i.
The questionnaire was filled out by a close relative or caregiver. The need for consensus on a diagnostic battery for MCI motivated the current study. Alzheimer’s disease, cognitive assessment, dementia, memory, mild cognitive impairment. MCI diagnoses were made according to the definitions proposed by Winblad et al. The classification of MCI was determined by a consensus by the aforementioned researchers PM and GC based on clinical data and neuropsychological results from the full battery.
The use of a brief battery might not be indicated to discriminate MCI and clinical-control individuals, but its use might be adequate to discriminate less specific groups demented versus non-demented and pathological [dementia and MCI] and non-pathological [clinical-control] groups.
Controversially to our results, another study conducted in Brazil 8 showed that brief batteries could accurately discriminate MCI from normal and demented individuals, although not sensitively enough to establish subtypes of MCI e. We also performed a post-hoc analysis of the tests used to compose the brief battery. Based on the literature review, we hypothesized that a minute battery would be suitable to discriminate the three groups with good sensitivity and specificity. Most studies focus on the amnestic subtype of MCI, single or multiple-domain 5as the best predictor of AD, which is the most prevalent dementia in the elderly 6which associate with significant impact even in initial in mild phase 7.
Agreement rates between the full comprehensive and brief batteries were calculated with the kappa statistics with quadratic weighting by considering three categorical diagnoses dementia, MCI, and normal. We found it to be important even though it does not help to discriminate normal individuals from those with MCI. This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it.
This image, work, or other file associated with it is an original work by Adam E. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Field Artillery Survey (MCI 0813A)
Tests of brief and full battery are listed in table 2. For example, 13 MCI subjects were incorrectly classified as having dementia, whereas 5 individuals with dementia were reclassified as MCI. The diagnoses generated by a brief battery were then compared to the golden standard diagnoses, as explained above.
Views View Edit History. Screening for mild cognitive impairment: The following tests complied with these criteria: The AUC was 0.
Assessment of memory complaint in age-associated memory impairment: In such cases where the image is specifically intended to depict a person or sporting event, then your use of this image may be restricted due to trademark, personality rights, or other rights of the league or teams involved independent of my rights as the photographer.
A meta-analysis of the accuracy of the mini-mental state examination in the detection of 801a and mild cognitive impairment.
Field Artillery Survey (MCI A) by Marine Corp Institute –
The results of the comparisons are summarized in table 3. Conclusion It should be stressed that the proposed brief battery alone does not provide an MCI diagnosis per sewhich requires clinical evaluation by the physician. When grouping MCI and normal individuals in the same group and comparing their performance to that of AD individuals, we found good sensitivity and specificity Analyses with ROC curves showed good sensitivity and specificity to discriminate non-demented clinical control plus MCI groups and AD group and also to discriminate clinical-control individuals from individuals with cognitive decline MCI plus AD group.
You alone are responsible for ensuring that your usage does not infringe on the rights of any third party. The comparison between MCI and the other groups mainly showed memory differences. Please see the usage guide and Wikimedia’s general disclaimer for more details. Working memory in early Alzheimer’s disease: From Wikimedia Commons, the free media repository.
Because our study was focused in individuals with memory complaints following other studies comprising amnestic MCIwe do not know whether our brief battery might be helpful in diagnosing non-amnestic MCI or non-Alzheimer dementias. Digit Span forward performances did not differ among the three groups, indicating that there were no differences in the phonological loop.